5-溴-N-甲基-2-硝基苯胺合成路线 （共 8 条）
反应条件
in tetrahydrofuran T=20°C; 0.166667 h;
参考文献
BIOGEN IDEC MA INC.; CHAO, Jianhua; ENYEDY, Istvan, J.; GUERTIN, Kevin; HUTCHINGS, Richard, H.; JONES, John, Howard; POWELL, Noel; VANVLOTEN, Kurt, D.
Patent: WO2014/8214 A1, 2014 ;
Location in patent: Paragraph 00327-00328 ;
反应条件
in ethanol; water 2 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2004/111046 A2, 2004 ;
Location in patent: Page/Page column 17-18 ;
WO 2004/111046 A2
反应条件
N-ethyl-N,N-diisopropylamine in acetonitrile T=60°C; 16 h;
参考文献
Gilead Palo Alto, Inc.
Patent: US2010/113461 A1, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
triethylamine in DMF (N,N-dimethyl-formamide) T=0 - 70°C;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GmbH; BOEHRINGER INGELHEIM PHARMA GmbH and CO KG
Patent: WO2005/80388 A1, 2005 ;
Location in patent: Page/Page column 94 ;
WO 2005/080388 A1
参考文献
Blanksma
Recueil des Travaux Chimiques des Pays-Bas, 1902 , vol. 21, p. 277,414
反应条件
sodium dithionite in ethanol; water
参考文献
WO2012/174312 A2, ;
Page/Page column 216-217 ;
WO 2012/174312 A2
反应条件
1: 5-bromo-N-methyl-2-nitroaniline With tin(ll) chloride in ethanol T=80°C; 4 h; 2: trimethyl orthoformate With toluene-4-sulfonic acid in toluene T=110°C; 15 h;
参考文献
WO2008/51808 A2, ;
Page/Page column 82-83 ;
WO 2008/051808 A2
反应条件
1: zinc; acetic acid / 0.58 h
2: tetrahydrofuran / 17 h / 23 °C / Reflux
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2012/21382 A1, 2012 ;
WO 2012/021382 A1
