1-乙炔基-2,4-二氟苯合成路线 （共 4 条）
反应条件
PPh3 gold(I) chloro complex; trimethylsilylazide; water; silver carbonate; trifluoroacetic acid in 1,2-dichloro-ethane T=60°C; Schlenk techniqueInert atmosphere;
参考文献
Qin, Chong; Feng, Peng; Ou, Yang; Shen, Tao; Wang, Teng; Jiao, Ning
Angewandte Chemie - International Edition, 2013 , vol. 52, # 30 p. 7850 - 7854
Angew. Chem., 2013 , vol. 125, # 30 p. 8004 - 8008
反应条件
copper(l) iodide; [Pd(PPh3)2(OAc)2]; triethylamine in dimethyl sulfoxide
T=25°C; Sonogashira coupling; 15 h;
参考文献
Magnus, Nicholas A.; Diseroad, William D.; Nevill Jr., C. Richard; Wepsiec, James P.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 556 - 560
反应条件
1: 67 percent / CuI; Et3N; Pd(PPh3)2(OAc)2 / dimethylsulfoxide / 15 h / 25 °C
2: 85 percent / aq. NaHCO3; MgSO4; KMnO4 / acetone / 1 h / 35 °C
View Scheme
参考文献
Magnus, Nicholas A.; Diseroad, William D.; Nevill Jr., C. Richard; Wepsiec, James P.
Organic Process Research and Development, 2006 , vol. 10, # 3 p. 556 - 560
反应条件
zinc(II) chloride in 1,2-dichloro-ethane
T=150°C; 0.25 h; microwave irradiation;
参考文献
Yeager, Adam R.; Min, Geanna K.; Porco Jr., John A.; Schaus, Scott E.
Organic Letters, 2006 , vol. 8, # 22 p. 5065 - 5068
