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乙二醇
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63148-62-9
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二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
达沙替尼
合成路线
（共 39 条）
1245157-85-0
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With water; sodium hydroxide T=50°C; 2 h; 2: With hydrogenchloride in water T=20 - 25°C; pH=4;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0278; 0279 ;
1245157-70-3
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With boron trichloride in dichloromethane T=-15 - 20°C; 2: With water in dichloromethane Cooling with ice;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0245 ;
1245157-72-5
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With boron trichloride in dichloromethane T=-15 - 20°C; 2: With water in dichloromethane Cooling with ice;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0245-0247 ;
1245157-78-1
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With boron trichloride in dichloromethane T=-15 - 20°C; 2: With water in dichloromethane Cooling with ice;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0245; 0250 ;
1245157-86-1
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With water; sodium hydroxide T=50°C; 2 h; 2: With hydrogenchloride in water T=20 - 25°C; pH=4;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0278-0281 ;
1245157-75-8
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With boron trichloride in dichloromethane T=-15 - 20°C; 2: With water in dichloromethane Cooling with ice;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0245; 0248 ;
1245157-77-0
→
反应条件
302962-49-8
达沙替尼
反应条件
1: With boron trichloride in dichloromethane T=-15 - 20°C; 2: With water in dichloromethane Cooling with ice;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0245; 0249 ;
1245157-35-0
+
87-63-8
2-氯-6-甲基苯胺
→
反应条件
302962-49-8
达沙替尼
反应条件
phenylphosphoric acid dichloride; triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0282; 0283; 0284 ;
103-76-4
1-(2-羟乙基)哌嗪
+
302964-08-5
N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺
→
反应条件
302962-49-8
达沙替尼
反应条件
N-ethyl-N,N-diisopropylamine in dimethyl sulfoxide T=110°C; 1 h; TemperatureTimeReagent/catalystSolvent;
参考文献
CADILA HEALTHCARE LIMITED; SINGH, Kumar Kamlesh Laxmi; SINGH, Nikhil Amar; PATHE, Gulab Khushalrao
Patent: WO2013/65063 A1, 2013 ;
Location in patent: Page/Page column 13 ;
1245157-42-9
+
87-63-8
2-氯-6-甲基苯胺
→
反应条件
302962-49-8
达沙替尼
反应条件
phenylphosphoric acid dichloride; triethylamine in dichloromethane T=0 - 20°C; Inert atmosphere; Product distribution / selectivity;
参考文献
Nan Jing Cavendish Bio-Engineering Technology Co. Ltd.; Yan, Rong; Yang, Hao; Hou, Wen; Xu, Yongxiang
Patent: US2013/30177 A1, 2013 ;
Location in patent: Paragraph 0170-0175 ;
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