N-叔丁氧羰基-2-氨基-4-甲基噻唑-5-甲酸合成路线 （共 3 条）
反应条件
potassium hydroxide in tetrahydrofuran; ethanol T=55°C;
参考文献
Das, Jagabandhu; Padmanabha, Ramesh; Chen, Ping; Norris, Derek J.; Doweyko, Arthur M.P.; Barrish, Joel C.; Wityak, John; Lombardo, Louis J.; Lee, Francis Y.F.
Patent: US2004/54186 A1, 2004 ;
Location in patent: Page 20 ;
US 20040054186 A1
反应条件
1: 72 percent / 4-dimethylaminopyridine / tetrahydrofuran / 18 h 2: 89 percent / aq. KOH / tetrahydrofuran; ethanol / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6819 - 6832
反应条件
1: 72 percent / 4-dimethylaminopyridine / tetrahydrofuran / 18 h 2: 89 percent / aq. KOH / tetrahydrofuran; ethanol / 55 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 49, # 23 p. 6819 - 6832
