N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺合成路线

N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺合成路线（共 15 条）

参考文献

BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2005/77945 A2, 2005 ;
Location in patent: Page/Page column 52 ;
WO 2005/077945 A2

103-76-41-(2-羟乙基)哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

302962-49-8达沙替尼

参考文献

CADILA HEALTHCARE LIMITED; SINGH, Kumar Kamlesh Laxmi; SINGH, Nikhil Amar; PATHE, Gulab Khushalrao
Patent: WO2013/65063 A1, 2013 ;
Location in patent: Page/Page column 13 ;

110-85-0哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺+

910297-61-9达沙替尼二聚杂质

参考文献

Arora, Vinod Kumar; Christopher, Lisa Joy; Cui, Donghui; Li, Wenying
Patent: US2006/211705 A1, 2006 ;
Location in patent: Page/Page column 28 ;

110-85-0哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

910297-51-7N-(2-氯-6-甲基苯基)-2-{[2-甲基-6-(1-哌嗪基)-4-嘧啶基]氨基}-1,3-噻唑-5-甲酰胺

参考文献

Veach, Darren R.; Namavari, Mohammad; Pillarsetty, Nagavarakishore; Santos, Elmer B.; Beresten-Kochetkov, Tatiana; Lambek, Caryl; Punzalan, Blesida J.; Antczak, Christophe; Smith-Jones, Peter M.; Djaballah, Hakim; Clarkson, Bayard; Larson, Steven M.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 23 p. 5853 - 5857

40004-08-81-(乙氧基羰甲基)哌嗪+

302964-08-5N-(2-氯-6-甲基苯基)-2-[(6-氯-2-甲基-4-嘧啶基)氨基]-5-噻唑甲酰胺

910297-62-0达沙替尼羧酸乙酯

参考文献

Bristol-Myers Squibb Company
Patent: US2007/219370 A1, 2007 ;
Location in patent: Page/Page column 29 ;

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