acetic acid in tetrahydrofuran; water; acetonitrile T=20°C; pH=7.5; 12 h;

hydrogenchloride in water

Streptomyces spheroides NovN enzyme; adenosine 5'-triphosphoric acid; bovine serum albumin; magnesium chloride in water; dimethyl sulfoxide T=20°C; pH=9.0; Enzyme kinetics;

1.1: 61 percent / p-toluenesulfonic acid / 60 °C 2.1: 100 percent / LiOH / tetrahydrofuran; H2O / 20 - 40 °C 3.1: 83 percent / Bu3P / CH2Cl2 / 72 h / 20 °C 4.1: 98 percent / trifluoroacetic acid / CH2Cl2; H2O / 20 °C 5.1: 49 percent / diethyl azodicarboxylate; PPh3 / CH2Cl2 / 20 °C 6.1: H2 / Pd/C / tetrahydrofuran; methanol 7.1: aniline; NaNO2; NaOAc / aq. HCl; methanol; tetrahydrofuran 7.2: Na2S2O4; NaOAc / ethanol; H2O; tetrahydrofuran 8.1: 85 percent / HATU; 4-methylmorpholine / dimethylformamide View Scheme