反应条件
<b>Multi-step reaction with 9 steps<br /> </b>1.1: 75 percent / PPh<sub>3</sub> / CH<sub>2</sub>Cl<sub>2</sub> / 0.17 h / 0 °C<br />2.1: tetrahydrofuran / 2.5 h / -78 - 0 °C<br />2.2: 70 percent / HMPA / tetrahydrofuran / -78 - 20 °C<br />3.1: 74 percent / AcOH / H<sub>2</sub>O / 16 h / 100 °C<br />4.1: 78 percent / tetrahydrofuran / -20 °C<br />5.1: 88 percent / propionic acid / 2 h / Heating<br />6.1: AD-mix-β; MeSO<sub>2</sub>NH<sub>2</sub> / 2-methyl-propan-2-ol; H<sub>2</sub>O / 16 h / 0 °C<br />7.1: KOH / H<sub>2</sub>O; methanol / 2 h / 60 °C<br />8.1: 1.5 g / TsOH / CH<sub>2</sub>Cl<sub>2</sub> / 1 h / 20 °C<br />9.1: 95 percent / TsOH / acetone / 0.5 h / 20 °C<br /> <br />
参考文献
Avedissian, Hovsep; Sinna, Santosh C.; Yazbak, Ahmad; Sinha, Anjana; Neogi, Partha; Sinha, Subhash C.; Keinan, Ehud Journal of Organic Chemistry, 2000 , vol. 65, # 19 p. 6035 - 6051
