1-(4-氯苯基)-2,2-二甲基-1-丙酮合成路线 （共 14 条）
反应条件
1: 1-chloro-4-bromobenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: pivalaldehyde in tetrahydrofuran; hexane T=-78°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 5 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
potassium hydroxide; 18-crown-6 ether in toluene T=70°C; 1 h;
参考文献
Lissel, Manfred; Neumann, Beate; Schmidt, Stefan
Liebigs Annalen der Chemie, 1987 , p. 263 - 264
反应条件
ozone in acetonitrile
参考文献
Tetrahedron, , vol. 41, # 11 p. 2169 - 2176
反应条件
1: tert.-butyl lithium With copper(I) bromide dimethylsulfide complex in tetrahydrofuran; pentane T=-78°C; Inert atmosphere; 2: 4-chloro-benzoyl chloride in tetrahydrofuran; pentane -78 h; Inert atmosphere;
参考文献
Diaz-Valenzuela, M. Belen; Phillips, Scott D.; France, Marcia B.; Gunn, Mary E.; Clarke, Matthew L.
Chemistry - A European Journal, 2009 , vol. 15, # 5 p. 1227 - 1232
反应条件
Fe2(S04)3 in hexane T=20°C; Friedel-Crafts acylation; 0.75 h; Sonication;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 50, # 9 p. 1192 - 1195
反应条件
in 1,2-dichloro-benzene T=180°C; 7 h; Inert atmosphere;
参考文献
Lo Fiego, Marcos J.; Lockhart, Maria T.; Chopa, Alicia B.
Journal of Organometallic Chemistry, 2009 , vol. 694, # 22 p. 3674 - 3678
反应条件
1: in tetrahydrofuran; pentane T=-78°C; 0.25 h; Inert atmosphere; 2: in tetrahydrofuran; N,N-dimethyl-formamide; pentane T=-70 - -10°C; Inert atmosphere; 3: With ammonium chloride in tetrahydrofuran; water; N,N-dimethyl-formamide; pentane Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 74, # 2 p. 795 - 809
反应条件
iodine 0.166667 h; Ambient temperatureIrradiation;
参考文献
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, , vol. 35, # 11 p. 1197 - 1198
反应条件
1: tert.-butyl lithium; 2-chloro-5-carboxybenzene in tetrahydrofuran; pentane T=-90°C; 2 h; 2: methyl iodide in tetrahydrofuran; pentane T=-90 - 20°C;
参考文献
Journal of Organic Chemistry, , vol. 70, # 4 p. 1501 - 1504
反应条件
chromium(VI) oxide; acetic acid
参考文献
Journal of the Chemical Society, , p. 2718,2721
