2,2-二甲基-1-(4-甲基苯基)丙-1-酮合成路线 （共 30 条）
反应条件
pyridine; 1,10-phenanthroline; tris-(o-tolyl)phosphine; copper(I) bromide in 1-methyl-pyrrolidin-2-one T=170°C; 36 h;
参考文献
SALTIGO GMBH
Patent: US2009/221832 A1, 2009 ;
Location in patent: Page/Page column 2-3 ;
反应条件
1: para-bromotoluene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: pivalaldehyde in tetrahydrofuran; hexane T=-78°C; 1 h; 3: With iodine; potassium carbonate in tert-butyl alcohol 16 h; Reflux;
参考文献
Ushijima, Sousuke; Dohi, Souya; Moriyama, Katsuhiko; Togo, Hideo
Tetrahedron, 2012 , vol. 68, # 5 p. 1436 - 1442
反应条件
1: With triethyl borane in hexane; toluene T=90°C; 4 h; Air atmosphere; 2: With water; sodium hydrogencarbonate in hexane; toluene
参考文献
Kim, Joong-Gon; Mishra, Mithilesh Kumar; Jang, Doo Ok
Tetrahedron Letters, 2012 , vol. 53, # 27 p. 3527 - 3529
反应条件
magnesium 1.) ether, 2.) ether, -15 deg C; Multistep reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 63, # 3 p. 856 - 866
反应条件
hydrogenchloride; sodium hydrogencarbonate; magnesium in tetrahydrofuran
反应条件
potassium hydroxide; 18-crown-6 ether in toluene T=70°C; 1 h;
参考文献
Lissel, Manfred; Neumann, Beate; Schmidt, Stefan
Liebigs Annalen der Chemie, 1987 , p. 263 - 264
反应条件
1: p-methylthiopivalophenone S-oxide With Lawesson's reagent in dichloromethane T=20°C; 1 h; 2: p-methylthiopivalophenone in dichloromethane T=20°C; 72 h;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 77, # 1 p. 187 - 188
反应条件
copper(I) oxide; 1,10-phenanthroline; tris(4-methylphenyl)-phosphine; PdI2 in 1-methyl-pyrrolidin-2-one T=170°C; 16 h; Inert atmosphere;
参考文献
Goossen, Lukas J.; Linder, Christophe; Rodriguez, Nuria; Lange, Paul P.
Chemistry - A European Journal, 2009 , vol. 15, # 37 p. 9336 - 9349
反应条件
in tetrahydrofuran; diethyl ether; Petroleum ether T=-110°C;
参考文献
Journal of Organic Chemistry, , vol. 58, # 21 p. 5843 - 5845
反应条件
tetrabutyl ammonium fluoride; oxygen; palladium diacetate; potassium carbonate in toluene T=100°C; P=760.051 Torr;
参考文献
Chemical Communications, , vol. 48, # 13 p. 1922 - 1924
