6-氯-5-氰基-2-甲基烟酸甲酯合成路线 (共 2 条)
反应条件
N-ethyl-N,N-diisopropylamine T=20°C; 1 h;
参考文献
ASTRAZENECA AB
Patent: WO2007/8140 A1, 2007 ;
Location in patent: Page/Page column 173 ;
WO 2007/008140 A1
反应条件
trichlorophosphate 41 h; Reflux;
参考文献
De Los Rios, Cristobal; Egea, Javier; Marco-Contelles, Jose; Leon, Rafael; Samadi, Abdelouahid; Iriepa, Isabel; Moraleda, Ignacio; Galvez, Enrique; Garcia, Antonio G.; Lopez, Manuela G.; Villarroya, Mercedes; Romero, Alejandro
Journal of Medicinal Chemistry, 2010 , vol. 53, # 14 p. 5129 - 5143