N-(4-(2-乙基-4-(3-甲基苯基)噻唑-5-基)吡啶-2-基)苯甲酰胺合成路线 （共 5 条）
反应条件
1: Et3N / tetrahydrofuran / 3 h / 20 °C 2: 59.8 g / HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
反应条件
1: 86 percent / Br2; AcOH / 3 h / 80 °C 2: 60 percent / dimethylformamide / 14 h / 20 °C 3: Et3N / tetrahydrofuran / 3 h / 20 °C 4: 59.8 g / HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: Et3N / tetrahydrofuran / 3 h / 20 °C 5.1: 59.8 g / HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
反应条件
1.1: BuLi / tetrahydrofuran; hexane / 0.5 h / 0 °C 1.2: 81 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: 86 percent / Br2; AcOH / 3 h / 80 °C 3.1: 60 percent / dimethylformamide / 14 h / 20 °C 4.1: Et3N / tetrahydrofuran / 3 h / 20 °C 5.1: 59.8 g / HCl / tetrahydrofuran; H2O / 14 h / 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 19 p. 5966 - 5979
参考文献
EP1180518 A1, ;
Example 16 ;
