(1’R,2S)-2-(1’,2’-二羟基乙基)-6-氟色满合成路线 （共 18 条）
反应条件
water; acetic acid T=60 - 65°C; 2.5 h;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64827 A2, 2008 ;
Location in patent: Page/Page column 28-29 ;
反应条件
sodium tetrahydroborate in tetrahydrofuran; hexane T=20°C; 0.5 h; Inert atmosphere; Overall yield = 18 g;
参考文献
Menarini International Operations Luxembourg S.A.; CIPOLLONE, Amalia; D'ANDREA, Piero; FATTORI, Daniela
Patent: WO2013/18053 A1, 2013 ;
Location in patent: Page/Page column 19; 20 ;
反应条件
hydrogenchloride; Zn–Hg amalgam in ethanol Clemmensen reduction;
参考文献
Wang, Nai-Xing; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen
Synthesis, 2007 , # 8 p. 1154 - 1158
反应条件
1: With oxygen; acetic acid; Jacobsen's (R,R)-(salen)Co(III) catalyst in tert-butyl methyl ether; toluene T=20°C; 1 h; 2: With water in tert-butyl methyl ether; toluene T=25°C; 24 h; Product distribution / selectivity;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64826 A1, 2008 ;
Location in patent: Page/Page column 28 ;
反应条件
water; acetic acid T=65°C; 3 h;
参考文献
ZACH SYSTEM S.P.A.
Patent: WO2008/64827 A2, 2008 ;
Location in patent: Page/Page column 35 ;
反应条件
1: 89 percent / AlCl3 / 2 h / 130 °C 2: 24 percent / pyrrolidine / toluene 3: 62 percent / hydrochloric acid; zinc / ethanol / 7 h / 65 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate T=-20°C; Cyclization; Sharpless asymmetric epoxidation; 4 h;
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1: 24 percent / pyrrolidine / toluene 2: 62 percent / hydrochloric acid; zinc / ethanol / 7 h / 65 °C View Scheme
参考文献
Yu, An-Guang; Wang, Nai-Xing; Xing, Ya-Lan; Zhang, Jun-Ping; Yang, Yun-Xu; Wang, Wu-Wei; Sheng, Rui-Long
Synlett, 2005 , # 9 art. no. U05005ST, p. 1465 - 1467
反应条件
1: AlCl3 / 130 °C 2: pyrrolidine / toluene 3: 62 percent / zinc amalgam; aq. HCl / ethanol View Scheme
参考文献
Yu, An-Guang; Wang, Nai-Xing; Xing, Ya-Lan; Zhang, Jun-Ping; Yang, Yun-Xu; Wang, Wu-Wei; Sheng, Rui-Long
Synlett, 2005 , # 9 art. no. U05005ST, p. 1465 - 1467
反应条件
1.1: 76 percent / 6 h / 210 °C 2.1: 84 percent / imidazole / CH2Cl2 / 10 h / 20 °C 3.1: BH3*DMS / tetrahydrofuran / 1.5 h / 10 °C 3.2: 75 percent / 30 percent H2O2 / 2 h / 0 °C 4.1: Dess-Martin periodinane; PhCO2H / CH2Cl2; dimethylsulfoxide / 0.5 h 5.1: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 6.1: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 7.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 8.1: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
