(1’R,2S)-2-(2’-对甲苯磺酰基-1’,2’-二羟基乙基)-6-氟色满合成路线 （共 12 条）
参考文献
Wang, Nai-Xing; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen
Synthesis, 2007 , # 8 p. 1154 - 1158
反应条件
1: 89 percent / AlCl3 / 2 h / 130 °C 2: 24 percent / pyrrolidine / toluene 3: 62 percent / hydrochloric acid; zinc / ethanol / 7 h / 65 °C 4: 85 percent / pyridine / 24 h View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1: 24 percent / pyrrolidine / toluene 2: 62 percent / hydrochloric acid; zinc / ethanol / 7 h / 65 °C 3: 85 percent / pyridine / 24 h View Scheme
参考文献
Wang, Nai-Xing; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen
Synthesis, 2007 , # 8 p. 1154 - 1158
反应条件
1: 62 percent / hydrochloric acid; zinc / ethanol / 7 h / 65 °C 2: 85 percent / pyridine / 24 h View Scheme
参考文献
Wang, Nai-Xing; Yu, An-Guang; Wang, Gui-Xia; Zhang, Xiu-Hui; Li, Qian-Shu; Li, Zhen
Synthesis, 2007 , # 8 p. 1154 - 1158
反应条件
1.1: 76 percent / 6 h / 210 °C 2.1: 84 percent / imidazole / CH2Cl2 / 10 h / 20 °C 3.1: BH3*DMS / tetrahydrofuran / 1.5 h / 10 °C 3.2: 75 percent / 30 percent H2O2 / 2 h / 0 °C 4.1: Dess-Martin periodinane; PhCO2H / CH2Cl2; dimethylsulfoxide / 0.5 h 5.1: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 6.1: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 7.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 8.1: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 9.1: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1.1: 84 percent / imidazole / CH2Cl2 / 10 h / 20 °C 2.1: BH3*DMS / tetrahydrofuran / 1.5 h / 10 °C 2.2: 75 percent / 30 percent H2O2 / 2 h / 0 °C 3.1: Dess-Martin periodinane; PhCO2H / CH2Cl2; dimethylsulfoxide / 0.5 h 4.1: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 5.1: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 6.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 7.1: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 8.1: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 2: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1.1: BH3*DMS / tetrahydrofuran / 1.5 h / 10 °C 1.2: 75 percent / 30 percent H2O2 / 2 h / 0 °C 2.1: Dess-Martin periodinane; PhCO2H / CH2Cl2; dimethylsulfoxide / 0.5 h 3.1: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 4.1: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 5.1: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 6.1: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 7.1: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 2: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 3: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 4: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 5: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1: Dess-Martin periodinane; PhCO2H / CH2Cl2; dimethylsulfoxide / 0.5 h 2: 4.4 g / CH2Cl2; dimethylsulfoxide / 10 h / 20 °C 3: 78 percent / DIBAL-H / CH2Cl2; hexane / 0 - 20 °C 4: 80 percent / TBAF / tetrahydrofuran / 3 h / 20 °C 5: 65 percent / (+)-DET; Ti(OPr-i)4; TBHP / 4 h / -20 °C 6: 82 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
