(1’S,2R)-2-(1’,2’-二羟基乙基)-6-氟色满合成路线 (共 2 条)
反应条件
1: 61 percent / DEAD; TPP / tetrahydrofuran / -20 - 20 °C 2: 72 percent / NaOMe / methanol / 3 h / 20 °C 3: 75 percent / pyridine / CH2Cl2 / 10 h / 20 °C View Scheme
参考文献
Chandrasekhar; Venkat Reddy
Tetrahedron, 2000 , vol. 56, # 34 p. 6339 - 6344
反应条件
1.1: dichloromethane / 25 - 30 °C 1.2: 0 - 5 °C 2.1: pyridine / 10 - 15 °C 3.1: potassium hydroxide / dimethyl sulfoxide / 20 °C 4.1: methanol / 17 h / Industry scale; Reflux 4.2: Industry scale View Scheme
参考文献
CADILA PHARMACEUTICALS LIMITED; KHAMAR, Bakulesh, Mafatlal; KAGATHARA, Nirav, Keshavlal; MUGALE, Balaji; KORIKANA, Sivaprasad; BAPAT, Uday, Rajaram; MODI, Indravadan, Ambalal
Patent: WO2011/132140 A2, 2011 ;