6-(氯甲基)-n-(4-氯苯基)-1,3,5-三嗪-2,4-二胺合成路线 （共 2 条）
反应条件
1: N1-(p-Chlorophenyl)biguanide hydrochloride With sodium methylate in methanol T=20°C; 3 h; 2: chloroacetic acid ethyl ester in methanol T=20°C; Reflux;
参考文献
Ma, Xiang; Poon, Thong-Yuen; Wong, Peter Tsun Hon; Chui, Wai-Keung
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 19 p. 5644 - 5647
反应条件
1.1: hydrogenchloride / water / Reflux 2.1: sodium methylate / methanol / 3 h / 20 °C 2.2: 48 h / 20 °C View Scheme
参考文献
Maarouf, Azza R.; Farahat, Abdelbasset A.; Selim, Khalid B.; Eisa, Hassan M.
Medicinal Chemistry Research, 2012 , vol. 21, # 6 p. 703 - 710
