2-甲基-2-丙基{1-[(6-氨基-2-吡啶基)甲基]-4-哌啶基}氨基甲酸酯合成路线 （共 8 条）
反应条件
monobutylphosphine; citric acid in toluene T=15 - 20°C; 0.5 h;
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: n-BuLi; n-BuMgCl / toluene; tetrahydrofuran; hexane / 3.5 h / -10 - -5 °C 1.2: 97 percent / toluene; tetrahydrofuran; hexane / 0.5 h / -10 - -5 °C 2.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 2.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 3.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 4.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: tetrahydrofuran; methanol / 1 h / 10 - 15 °C 2.1: 258 g / H2 / Pd/C / tetrahydrofuran; methanol / 4 h / 30 °C / 3420.23 - 3800.26 Torr 3.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 3.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 4.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 5.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 1.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 2.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 3.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: tetrahydrofuran; methanol / 1 h / 10 - 15 °C 2.1: 258 g / H2 / Pd/C / tetrahydrofuran; methanol / 4 h / 30 °C / 3420.23 - 3800.26 Torr 3.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 3.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 4.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 5.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1.1: 258 g / H2 / Pd/C / tetrahydrofuran; methanol / 4 h / 30 °C / 3420.23 - 3800.26 Torr 2.1: toluene; tetrahydrofuran / 0.5 h / 15 - 20 °C 2.2: 80 percent / NaBH(OAc)3 / toluene; tetrahydrofuran; dimethylsulfoxide / 5.5 h / 15 - 20 °C 3.1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 4.1: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
1: 1,1'-bis(diphenylphosphanyl)ferrocene; t-BuONa / Pd(OAc)2 / toluene / 1 h / 78 - 82 °C 2: 3600 g / n-butylphosphine; aqueous citric acid / toluene / 0.5 h / 15 - 20 °C View Scheme
参考文献
Mase; Houpis; Akao; Dorziotis; Emerson; Hoang; Iida; Itoh; Kamei; Kato; Kawasaki; Lang; Lee; Lynch; Maligres; Molina; Nemoto; Okada; Reamer; Song; Tschaen; Wada; Zewge; Volante; Reider; Tomimoto
Journal of Organic Chemistry, 2001 , vol. 66, # 20 p. 6775 - 6786
反应条件
copper(I) oxide; ammonia
参考文献
Lang, Fengrui; Zewge, Daniel; Houpis, Ioannis N.; Volante
Tetrahedron Letters, 2001 , vol. 42, # 19 p. 3251 - 3254
