1: 93 percent / H2 / 10percent Pd/C / ethanol; acetic acid / Ambient temperature 2: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C 3: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h 4: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C 5: H2 / PtO2, Pd / acetic acid View Scheme

1: 93 percent / H2 / 10percent Pd/C / ethanol; acetic acid / Ambient temperature 2: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C 3: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h 4: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C 5: H2 / PtO2, Pd / acetic acid View Scheme

hydrogen; palladium 10 on activated carbon in ethanol; dichloromethane T=20°C; 4 h;

1.1: 69.5 percent / BCl3 / CH2Cl2 / 20 °C 2.1: Et3N / CH2Cl2 2.2: H2O; Et3N / CH2Cl2 2.3: 60.5 percent / ethanol / 72 h / 70 - 80 °C View Scheme

1: 93 percent / H2 / 10percent Pd/C / ethanol; acetic acid / Ambient temperature 2: N,N-diisopropylethylamine / tetrahydrofuran / 0.75 h / -78 °C 3: N,N-diisopropylethylamine / tetrahydrofuran / -78 °C / -78 deg C, 2 h; r.t., 1 h 4: 30percent H2O2 / CH2Cl2 / 1 h / 0 °C 5: H2 / PtO2, Pd / acetic acid View Scheme

Multi-step reaction with 4 steps 1: Pseudomonas cepacia lipase / diisopropyl ether / 66 h / 20 °C2: triphenylphosphine; diethyl azodicarboxylate / diethyl ether3: Pseudomonas cepacia lipase; potassium dihydrogen phosphate; potassium hydrogen phosphate / diisopropyl ether / 34 h / 20 °C / pH 74: 96 percent / 4-dimethylaminopyridine; dicyclohexylcarbodiimide / CH2Cl2 / 0 - 20 °C