3-(溴甲基)-2-氟吡啶合成路线 (共 2 条)
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; Inert atmosphereCooling with ice;
参考文献
GLAXO GROUP LIMITED; Castro Pichel, Julia; Fernandez Menendez, Raquel; Fernandez Velando, Esther Pilar; Gonzalez Del Valle, Silvia; Mallo-Rubio, Araceli
Patent: US2013/203802 A1, 2013 ;
Location in patent: Paragraph 0250; 0251 ;
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in chloroform 30 h; Heating;
参考文献
Wagner, Stefan; Breyholz, Hans-Joerg; Law, Marilyn P.; Faust, Andreas; Hoeltke, Carsten; Schroeer, Sandra; Haufe, Guenter; Levkau, Bodo; Schober, Otmar; Schaefers, Michael; Kopka, Klaus
Journal of Medicinal Chemistry, 2007 , vol. 50, # 23 p. 5752 - 5764