4-氰基四氢-2H-吡喃-4-羧酸乙酯合成路线 （共 4 条）
反应条件
1: cyanoacetic acid ethyl ester With sodium hydride in N,N-dimethyl-formamide T=0 - 20°C; 2.41667 h; 2: 1-chloro-2-(2-chloroethoxy)ethane in N,N-dimethyl-formamide T=20 - 90°C; 17 h;
参考文献
WO2011/71716 A1, ;
Page/Page column 81-82 ;
WO 2011/071716 A1
参考文献
Bulletin de la Societe Chimique de France, , p. 3070 - 3075
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 4 h;
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOYER, Stephen, James; GAO, Donghong, Amy; GUO, Xin; KIRRANE, Thomas, Martin, Jr.; SARKO, Christopher, Ronald; SNOW, Roger, John; SOLEYMANZADEH, Fariba; ZHANG, Yunlong
Patent: WO2011/71716 A1, 2011 ;
Location in patent: Page/Page column 82 ;
WO 2011/071716 A1
参考文献
Gibson; Johnson
Journal of the Chemical Society, 1930 , p. 2525,2529
