1: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 2: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 3: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C View Scheme

1: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 2: t-BuOK / tetrahydrofuran / 0.5 h / 0 °C 3: NBS / 1 h / 20 °C 4: H(+) / acetonitrile / 1 h / 20 °C 5: K2CO3 / dimethylformamide / 2 h / 20 °C 6: 62 percent / H2 / 20percent Pd(OH)2/C / methanol / 3.5 h / 20 °C 7: H2O / 0.25 h / 80 °C View Scheme

1: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 2: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 3: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C 4: aq. HCl / acetonitrile / 1 h / 20 °C 5: 1.58 g / K2CO3 / dimethylformamide / 1 h / 20 °C 6: 62 percent / H2 / Pd(OH)2/C / methanol / 4 h / 20 °C View Scheme