(3As,7as)-苄基2-(溴甲基)-2-甲氧基六氢呋喃并[3,2-b]吡啶-4(2H)-羧酸合成路线 （共 7 条）
反应条件
N-bromosuccinmide in tetrahydrofuran T=20°C; 1 h;
参考文献
Takeuchi, Yasuo; Azuma, Kumiko; Takakura, Kentaro; Abe, Hitoshi; Kim, Hye-Sook; Wataya, Yusuke; Harayama, Takashi
Tetrahedron, 2001 , vol. 57, # 7 p. 1213 - 1218
反应条件
1: 62 percent / baker's yeast; sucrose; K2CO3 / H2O; ethanol / 90 h / 15 °C 2: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 3: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 4: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Takeuchi; Azuma; Takakura; Abe; Harayama
Chemical Communications, 2000 , # 17 p. 1643 - 1644
反应条件
1: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 2: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 3: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Takeuchi; Azuma; Takakura; Abe; Harayama
Chemical Communications, 2000 , # 17 p. 1643 - 1644
反应条件
1: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 2: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Takeuchi; Azuma; Takakura; Abe; Harayama
Chemical Communications, 2000 , # 17 p. 1643 - 1644
反应条件
1: 67 percent / K2CO3 / methanol / 4 h / 20 °C 2: 62 percent / baker's yeast; sucrose; K2CO3 / H2O; ethanol / 90 h / 15 °C 3: 87 percent / NBS / acetonitrile / 0.5 h / 20 °C 4: potassium tert-butoxide / tetrahydrofuran / 0.25 h / 20 °C 5: 2.17 g / NBS / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Takeuchi, Yasuo; Azuma, Kumiko; Takakura, Kentaro; Abe, Hitoshi; Kim, Hye-Sook; Wataya, Yusuke; Harayama, Takashi
Tetrahedron, 2001 , vol. 57, # 7 p. 1213 - 1218
反应条件
1: H(+) / acetonitrile / 1 h / 20 °C 2: K2CO3 / dimethylformamide / 2 h / 20 °C 3: 62 percent / H2 / 20percent Pd(OH)2/C / methanol / 3.5 h / 20 °C 4: H2O / 0.25 h / 80 °C View Scheme
参考文献
Takeuchi; Azuma; Takakura; Abe; Harayama
Chemical Communications, 2000 , # 17 p. 1643 - 1644
反应条件
1: aq. HCl / acetonitrile / 1 h / 20 °C 2: 1.58 g / K2CO3 / dimethylformamide / 1 h / 20 °C 3: 62 percent / H2 / Pd(OH)2/C / methanol / 4 h / 20 °C View Scheme
参考文献
Takeuchi; Azuma; Takakura; Abe; Harayama
Chemical Communications, 2000 , # 17 p. 1643 - 1644
