2-(哌啶-4-基)苯甲腈合成路线 （共 8 条）
反应条件
hydrogenchloride in 1,4-dioxane 1 h;
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
Location in patent: Page/Page column 68 ;
WO 2011/033255 A1
反应条件
1: 63 percent / TFA; H2SO4; 1,3-dibromo-5,5-dimethylhydantoin / 6 h / 24 - 31 °C 2: 82 percent / K3PO4 / Pd(PPh3)4 / dioxane; H2O / 11 h / 85 °C 3: H2 View Scheme
参考文献
Boice, Genevieve N.; Savarin, Cecile G.; Murry, Jerry A.; Conrad, Karen; Matty, Louis; Corley, Edward G.; Smitrovich, Jacqueline H.; Hughes, Dave
Tetrahedron, 2004 , vol. 60, # 50 p. 11367 - 11374
反应条件
1: 82 percent / K3PO4 / Pd(PPh3)4 / dioxane; H2O / 11 h / 85 °C 2: H2 View Scheme
参考文献
Boice, Genevieve N.; Savarin, Cecile G.; Murry, Jerry A.; Conrad, Karen; Matty, Louis; Corley, Edward G.; Smitrovich, Jacqueline H.; Hughes, Dave
Tetrahedron, 2004 , vol. 60, # 50 p. 11367 - 11374
反应条件
1: K3PO4 / Pd(PPh3)4 / dioxane; H2O / 85 °C 2: H2 View Scheme
参考文献
Boice, Genevieve N.; Savarin, Cecile G.; Murry, Jerry A.; Conrad, Karen; Matty, Louis; Corley, Edward G.; Smitrovich, Jacqueline H.; Hughes, Dave
Tetrahedron, 2004 , vol. 60, # 50 p. 11367 - 11374
反应条件
1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether; water; industrial methylated spirit / 0.3 h / 120 °C / Inert atmosphere; Microwave irradiation 2: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux 3: hydrogenchloride / 1,4-dioxane / 1 h View Scheme
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
反应条件
1: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux 2: hydrogenchloride / 1,4-dioxane / 1 h View Scheme
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
反应条件
1: caesium carbonate / tetrakis(triphenylphosphine) palladium(0) / ethylene glycol dimethyl ether; water; industrial methylated spirit / 0.3 h / 120 °C / Inert atmosphere; Microwave irradiation 2: ammonium formate / palladium 10 on activated carbon / water; industrial methylated spirit / 0.5 h / Reflux 3: hydrogenchloride / 1,4-dioxane / 1 h View Scheme
参考文献
THE UNIVERSITY OF EDINBURGH; WEBSTER, Scott, Peter; SECKL, Jonathan, Robert; WALKER, Brian, Robert; WARD, Peter; PALLIN, Thomas, David; DYKE, Hazel, Joan; PERRIOR, Trevor, Robert
Patent: WO2011/33255 A1, 2011 ;
WO 2011/033255 A1
参考文献
Boice, Genevieve N.; Savarin, Cecile G.; Murry, Jerry A.; Conrad, Karen; Matty, Louis; Corley, Edward G.; Smitrovich, Jacqueline H.; Hughes, Dave
Tetrahedron, 2004 , vol. 60, # 50 p. 11367 - 11374
