2,3-二氢-2-甲基-4(1h)-喹啉酮合成路线 (共 5 条)
反应条件
PPA T=110°C; Friedel Crafts reaction; 6 h;
参考文献
Liu, Jiwen; Wang, Yingcai; Sun, Ying; Marshall, Derek; Miao, Shichang; Tonn, George; Anders, Penny; Tocker, Joel; Tang, H. Lucy; Medina, Julio
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 24 p. 6840 - 6844
反应条件
1: toluene / 20 h / Heating 2: polyphosphoric acid / 6 h / 110 °C View Scheme
参考文献
Zhi, Lin; Tegley, Christopher M.; Marschke, Keith B.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1008 - 1012
反应条件
potassium carbonate; palladium; cis-maleic acid weitere Reagentien: Palladium/Kohle und Wasser;
参考文献
E. Lilly and Co.
Patent: US2558211 , 1949 ;
反应条件
triethylsilane; boron trifluoride diethyl etherate in dichloromethane T=100°C; 24 h;
参考文献
Zhi, Lin; Tegley, Christopher M.; Marschke, Keith B.; Jones, Todd K.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 7 p. 1008 - 1012
反应条件
acetic acid 2 h; RefluxInert atmosphere;
参考文献
Lei, Bai-Lin; Ding, Chang-Hua; Yang, Xiao-Fei; Wan, Xiao-Long; Hou, Xue-Long
Journal of the American Chemical Society, 2009 , vol. 131, # 51 p. 18250 - 18251