N-(ALPHA,ALPHA,ALPHA-三氟对甲苯)哌嗪合成路线 （共 9 条）
反应条件
1: With sodium t-butanolate; dicyclohexyl(2′,6′-dimethoxybiphenyl-2-yl)phosphine; bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran; tributyl-amine T=110°C; 8 h; 2: With hydrogenchloride in water pH=3; 3: With sodium hydroxide in water pH=10; Product distribution / selectivity;
参考文献
LANXESS Deutschland GmbH
Patent: US2005/250791 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
1: With sodium t-butanolate; palladium diacetate; 2-(dicyclohexylphosphino)-2',4',6'-tri-i-propyl-1,1’-biphenyl in tetrahydrofuran; toluene T=110°C; 8 h; 2: With hydrogenchloride in water pH=3; 3: With sodium hydroxide in water pH=10; Product distribution / selectivity;
参考文献
LANXESS Deutschland GmbH
Patent: US2005/250791 A1, 2005 ;
Location in patent: Page/Page column 4 ;
反应条件
1: piperazine With [2,2']bipyridinyl; nickel diacetate; sodium hydride; 1,1-dimethylpropan-1-ol in tetrahydrofuran T=65°C; 2 h; 2: 1-chloro-4-(trifluoromethyl)benzene With styrene in tetrahydrofuran T=65°C; 6 h;
参考文献
Tetrahedron, , vol. 58, # 34 p. 6913 - 6924
反应条件
tris-(dibenzylideneacetone)dipalladium(0) in methanol; dichloromethane; toluene
参考文献
US2014/142114 A1, ;
Page/Page column ;
反应条件
1.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl; tris-(dibenzylideneacetone)dipalladium(0) / toluene / 100 °C 2.1: trifluoroacetic acid / dichloromethane / 2 h / 30 °C 2.2: pH 7 - 8 View Scheme
参考文献
WO2011/28947 A2, ;
WO 2011/028947 A1
参考文献
Agarwal, Kamlesh C.
Journal of the Indian Chemical Society, 1980 , vol. 57, # 11 p. 1170 - 1171
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane T=100°C; Inert atmosphereSealed tube;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 61 ;
WO 2011/028947 A1
反应条件
1.1: potassium phosphate / tri-cyclo-hexyl-phosphine; tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 100 °C / Inert atmosphere; Sealed tube 2.1: hydrogen; trifluoroacetic acid / 5 Pd(II)/C(eggshell) / methanol / 30 °C 2.2: pH 8 - 9 View Scheme
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
WO 2011/028947 A1
反应条件
potassium hydroxide in diethyl ether; ethanol
参考文献
Rhone-Poulenc Sante
Patent: US4547504 A1, 1985 ;
