(3,4-二氢-2H-吡喃-6-基)二甲基硅醇合成路线 (共 2 条)
反应条件
1: 3,4-dihydro-2H-pyran With tert.-butyl lithium in tetrahydrofuran T=-78 - 0°C; Metallation; 2: cyclo-(Me2SiO)3 T=-78 - 0°C; Substitution;
参考文献
Denmark, Scott E.; Neuville, Luc
Organic Letters, 2000 , vol. 2, # 20 p. 3221 - 3224
反应条件
1: [2-(5,6-dihydro-4H-pyranyl)]dimethylsilanol With tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; desilylation; 2: 1-iodo-2-methylbenzene With bis(dibenzylideneacetone)-palladium(0) in tetrahydrofuran T=20°C; cross-coupling; 0.333333 h;
参考文献
Denmark, Scott E.; Neuville, Luc
Organic Letters, 2000 , vol. 2, # 20 p. 3221 - 3224