2-三氟甲基嘧啶-5-羧酸乙酯合成路线 （共 6 条）
反应条件
hydrogen; N-ethyl-N,N-diisopropylamine; palladium 10 on activated carbon in ethanol; dichloromethane P=760.051 Torr; 2 h;
参考文献
SmithKline Beecham p.l.c.
Patent: US2004/167142 A1, 2004 ;
Location in patent: Page/Page column 23 ;
反应条件
1: (COCl)2 / CH2Cl2 2: H2; iPrNEt / Pd/C / ethanol View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 1 p. 51 - 55
反应条件
in ethanol Condensation; cyclization; 3 h; Heating;
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
hydrogenchloride; diisobutylaluminium hydride in toluene T=-78°C; 0.75 h; Cooling with acetone-dry ice;
参考文献
SmithKline Beecham p.l.c.
Patent: US2004/167142 A1, 2004 ;
Location in patent: Page/Page column 23;24 ;
反应条件
1: 87 percent / aq. NaOH / tetrahydrofuran 2: 66 percent / (COCl)2; DMF / CH2Cl2 View Scheme
参考文献
Palanki; Erdman; Gayo-Fung; Shevlin; Sullivan; Goldman; Ransone; Bennett; Manning; Suto
Journal of medicinal chemistry, 2000 , vol. 43, # 21 p. 3995 - 4004
反应条件
1.1: DIBAL-h / toluene; dichloromethane / 3 h / -78 °C 1.2: 20 °C 2.1: sodium acetate / acetic acid / 20 °C 3.1: ammonium hydroxide; hydrogen / methanol / 0.42 h / 20 °C / 1551.49 Torr / |Inert atmosphere View Scheme
