2-(2-氨基-5-溴苯基)-2-丙醇合成路线 （共 20 条）
反应条件
1: 100 percent / tetrahydrofuran / 50 °C 2: sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
1.1: 100 percent / tetrahydrofuran / 50 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C 3.1: sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6498154 B1, 2002 ;
反应条件
in toluene T=20°C; 0.166667 h;
参考文献
American Home Products Corporation; Ligand Pharmaceuticals, Inc.
Patent: US6358948 B1, 2002 ;
Location in patent: Example 13 ;
反应条件
1: 100 percent / tetrahydrofuran / 50 °C 2: sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
1.1: 100 percent / tetrahydrofuran / 50 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
1: 100 percent / tetrahydrofuran / 50 °C 2: 82 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
1: in tetrahydrofuran 2.33333 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
Wyeth
Patent: US2005/239779 A1, 2005 ;
Location in patent: Page/Page column 13 ;
反应条件
1.1: 100 percent / tetrahydrofuran / 50 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C 3.1: 25 percent / sodium carbonate; tetrakis(triphenylphosphine)palladium / 1,2-dimethoxy-ethane; H2O / 3 h / 85 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
in tetrahydrofuran T=50°C;
参考文献
American Home Products Corporation
Patent: US2002/68735 A1, 2002 ;
US 20020068735 A1
