(4,4-二甲基-2-氧代-1,4-二氢-2H-3,1-苯并恶嗪-6-基)硼酸合成路线 （共 7 条）
反应条件
1: 6-bromo-4,4-dimethyl-1,4-dihydro-benzo[d][1,3]oxazin-2-one With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: tri-isopropoxy-borane in tetrahydrofuran; hexane T=-78 - 20°C; 3: With hydrogenchloride in tetrahydrofuran; hexane T=20°C; Further stages.;
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6436929 B1, 2002 ;
US 6436929 B1
反应条件
1.1: 100 percent / tetrahydrofuran / 50 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: tetrahydrofuran; hexane / -78 - 20 °C 2.3: 81 percent / aq. hydrochloric acid / tetrahydrofuran; hexane / 20 °C View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Fensome, Andrew; Wrobel, Jay; Winneker, Richard; Lundeen, Scott; Marschke, Keith B.; Zhang, Zhiming
Journal of Medicinal Chemistry, 2002 , vol. 45, # 20 p. 4379 - 4382
反应条件
tetrakis(triphenylphosphine) palladium(0); sodium carbonate in ethylene glycol dimethyl ether; water T=85°C; 3 h;
参考文献
Wyeth; Ligand Pharmaceuticals, Inc.
Patent: US6436929 B1, 2002 ;
US 6436929 B1
