2-(Boc-氨基)-4-羟甲基吡啶合成路线 （共 14 条）
反应条件
sodium hypochlorite; sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl in dichloromethane T=0°C; 0.333333 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/108958 A2, 2008 ;
Location in patent: Page/Page column 32 ;
反应条件
1: triethylamine / tetrahydrofuran / 0 - 20 °C 2: 11.24 g / dimethylformamide / 50 °C 3: 100 percent / H2NNH2*H2O / methanol; CHCl3 / 24 h / 20 °C View Scheme
参考文献
Kuramochi, Takahiro; Kakefuda, Akio; Yamada, Hiroyoshi; Tsukamoto, Issei; Taguchi, Taku; Sakamoto, Shuichi
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 12 p. 4022 - 4036
反应条件
1: With trifluoroacetic acid in dichloromethane T=0 - 20°C; 25.1833 h; 2: With ammonia in methanol; dichloromethane
参考文献
SCHERING CORPORATION
Patent: WO2007/1975 A1, 2007 ;
Location in patent: Page/Page column 51 ;
WO 2007/001975 A1
反应条件
thionyl chloride in dichloromethane
T=25°C; 2 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22561 A1, 2004 ;
Location in patent: Page 96 ;
WO 2004/022561 A1
