2-Boc-氨基-4-甲酰基吡啶合成路线 （共 5 条）
反应条件
sodium hypochlorite; sodium hydrogencarbonate; sodium bromide; 2,2,6,6-tetramethyl-piperidine-N-oxyl in dichloromethane T=0°C; 0.333333 h;
参考文献
SCHERING CORPORATION
Patent: WO2008/108958 A2, 2008 ;
Location in patent: Page/Page column 32 ;
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol; acetone / 15 h / 20 °C 2: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C 3: Dess-Martin periodane / dichloromethane / 15 h View Scheme
参考文献
Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
反应条件
1: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C 2: Dess-Martin periodane / dichloromethane / 15 h View Scheme
参考文献
Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
反应条件
1: 4-(N,N-dimethlyamino)pyridine / tert-butyl alcohol; acetone / 15 h / 20 °C 2: sodium tetrahydroborate; calcium chloride / ethanol / 7 h / 20 °C 3: Dess-Martin periodane / dichloromethane / 15 h View Scheme
参考文献
Poon, Jia-Fei; Alao, John Patrick; Sunnerhagen, Per; Diner, Peter
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 27 p. 4526 - 4536
反应条件
sodium tetrahydroborate in tetrahydrofuran; methanol T=0 - 25°C; 12 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22561 A1, 2004 ;
Location in patent: Page 96 ;
WO 2004/022561 A1
