1-[(2-氟苯基)甲基]-1H-吡唑并[3,4-b]吡啶-3-甲亚氨酸甲酯合成路线 (共 2 条)
反应条件
ammonium chloride; acetic acid in methanol 8 h; Heating;
参考文献
Bayer HealthCare AG
Patent: US6833364 B1, 2004 ;
Location in patent: Page column 34 ;
反应条件
1: 76.4 percent / NH4Cl; HOAc / methanol / 8 h / Heating 2: 31.8 percent / toluene / 8 h / Heating View Scheme
参考文献
Straub, Alexander; Stasch, Johannes-Peter; Alonso-Alija, Cristina; Benet-Buchholz, Jordi; Ducke, Bernhard; Feurer, Achim; Fuerstner, Chantal
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 781 - 784