[5-(6-氨基嘌呤-9-基)-4-羟基-2-(羟基甲基)四氢呋喃-3-基][5-(2,4-二氧代嘧啶-1-基)-3,4-二羟基四氢呋喃-2-基]甲基磷酸氢酯合成路线 （共 20 条）
反应条件
pyridine; ammonia; methoxybenzene; trifluoroacetic acid 1.) 12 h, 55 deg C, 2.) 0 deg C, 4 h; Yield given. Multistep reaction;
参考文献
Losse, G.; Pechstein, Birgit
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 1 p. 46 - 54
反应条件
1: 76 percent / pyridine / 2 h / Ambient temperature 2: 1) Silver acetate / 1) pyridine, room temperature, 15 min 2) 20 deg C 3: 20percent formic acid / 2 h / 40 °C View Scheme
参考文献
Agrawal, Sudhir; Misra, Krishna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 132 - 134
反应条件
1: 1) Silver acetate / 1) pyridine, room temperature, 15 min 2) 20 deg C 2: 20percent formic acid / 2 h / 40 °C View Scheme
参考文献
Agrawal, Sudhir; Misra, Krishna
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1980 , vol. 19, # 2 p. 132 - 134
反应条件
1: DMF; dioxane; tributylamine 2: chlorophosphoric acid diphenyl ester; tributylamine; dioxane / Behandeln des Reaktionsprodukts mit wss.NH3 View Scheme
参考文献
Michelson
Journal of the Chemical Society, 1959 , p. 3655,3664,3666
Biochemical Preparations, 1963 , vol. 10, p. 131
反应条件
1: chlorocarbonic acid ethyl ester; aqueous tributylamine 2: DMF; dioxane; tributylamine 3: chlorophosphoric acid diphenyl ester; tributylamine; dioxane / Behandeln des Reaktionsprodukts mit wss.NH3 View Scheme
参考文献
Michelson
Journal of the Chemical Society, 1959 , p. 3655,3664,3666
Biochemical Preparations, 1963 , vol. 10, p. 131
反应条件
1,4-dioxane; tributyl-amine; phenylphosphorochloridate Behandeln des Reaktionsprodukts mit wss.NH3;
参考文献
Michelson
Journal of the Chemical Society, 1959 , p. 3655,3664,3666
Biochemical Preparations, 1963 , vol. 10, p. 131
参考文献
Hayes, J. A.; Brunden, M. J.; Gilham, P. T.; Gough, G. R.
Tetrahedron Letters, 1985 , vol. 26, # 20 p. 2407 - 2410
反应条件
zinc dinitrate; sodium nitrate; HEPES buffer in water T=90.1°C; Rate constant;
参考文献
Wang, Qi; Loennberg, Harri
Journal of the American Chemical Society, 2006 , vol. 128, # 33 p. 10716 - 10728
反应条件
Zn(NO3)2*TPHP T=50°C; pH=7.0; Kinetics; Further Variations:Reagents;
参考文献
Yashiro, Morio; Kaneiwa, Hideki; Onaka, Kenichi; Komiyama, Makoto
Dalton transactions (Cambridge, England : 2003), 2004 , # 4 p. 605 - 610
反应条件
Zn(NO3)2*TPHP T=50°C; pH=7.0; Kinetics; Further Variations:Reagents;
参考文献
Yashiro, Morio; Kaneiwa, Hideki; Onaka, Kenichi; Komiyama, Makoto
Dalton transactions (Cambridge, England : 2003), 2004 , # 4 p. 605 - 610
