1-Boc-3-(溴甲基)吡咯烷合成路线 （共 5 条）
反应条件
carbon tetrabromide; triphenylphosphine in dichloromethane T=20°C; 18 h;
参考文献
WO2007/58850 A2, ;
Page/Page column 52-53 ;
WO 2007/058850 A2
反应条件
lithium bromide in acetone Heating;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: ammonium formate / Pd/C / methanol / 0.25 h / Heating 2: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C 3: 97 percent / Et3N / CH2Cl2 / 0 - 20 °C 4: 78 percent / LiBr / acetone / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: Red-Al / toluene; tetrahydrofuran / 2.5 h / Heating 2: ammonium formate / Pd/C / methanol / 0.25 h / Heating 3: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C 4: 97 percent / Et3N / CH2Cl2 / 0 - 20 °C 5: 78 percent / LiBr / acetone / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
反应条件
1: 3.82 g / K2CO3 / tetrahydrofuran; H2O / 0 - 20 °C 2: 97 percent / Et3N / CH2Cl2 / 0 - 20 °C 3: 78 percent / LiBr / acetone / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 12, # 5 p. 1151 - 1175
