5-(叔丁氧羰基氨基)-2-氟异烟酸甲酯合成路线 （共 9 条）
反应条件
n-butyllithium in methanol; hexane; chloroform T=0 - 20°C;
参考文献
American Cyanamid Company
Patent: US6355636 B1, 2002 ;
Location in patent: Page column 65 ;
US 6355636 B1
反应条件
in methanol; hexane; chloroform T=0 - 20°C; 2 h;
参考文献
Wyeth Holdings Corporation
Patent: EP1171440 B1, 2004 ;
Location in patent: Page 53-54 ;
反应条件
1.1: 70 percent / H2 / Raney Ni / ethyl acetate 2.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C 3.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C 3.2: diethyl ether 4.1: methanol; CHCl3; hexane / 2 h / 0 - 20 °C View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: 84 percent / KF / dimethylsulfoxide / 18 h / 70 °C 2.1: 70 percent / H2 / Raney Ni / ethyl acetate 3.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C 4.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C 4.2: diethyl ether 5.1: methanol; CHCl3; hexane / 2 h / 0 - 20 °C View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 °C 2.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C 2.2: diethyl ether 3.1: methanol; CHCl3; hexane / 2 h / 0 - 20 °C View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 °C 1.2: diethyl ether 2.1: methanol; CHCl3; hexane / 2 h / 0 - 20 °C View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 1.2: AcOH / tetrahydrofuran / -78 - 20 °C 2.1: dimethylformamide / 5 h / 20 °C 3.1: 70 percent / (COCl)2; DMF / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 1.2: AcOH / tetrahydrofuran / -78 - 20 °C 2.1: dimethylformamide / 5 h / 20 °C 3.1: 70 percent / (COCl)2; DMF / CH2Cl2 / 2 h / Heating 4.1: ethanol / 8 h / Heating View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
反应条件
1.1: n-BuLi / tetrahydrofuran / 1 h / -78 °C 1.2: AcOH / tetrahydrofuran / -78 - 20 °C 2.1: dimethylformamide / 5 h / 20 °C View Scheme
参考文献
Wissner, Allan; Hamann, Philip R.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Ye, Fei; Rapuano, Timothy A.; Loganzo, Frank
Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 6 p. 1411 - 1416
