1: dimethylformamide / 5 h / 20 °C 2: 70 percent / (COCl)2; DMF / CH2Cl2 / 2 h / Heating View Scheme

1: dimethylformamide / 5 h / 20 °C 2: 70 percent / (COCl)2; DMF / CH2Cl2 / 2 h / Heating 3: ethanol / 8 h / Heating View Scheme

N,N-dimethyl-formamide in methanol; water 1 h;

N,N-dimethyl-formamide dimethyl acetal in DMF (N,N-dimethyl-formamide) 1 h;

<b>Multi-step reaction with 6 steps<br /> </b>1.1: 84 percent / KF / dimethylsulfoxide / 18 h / 70 &deg;C<br />2.1: 70 percent / H₂ / Raney Ni / ethyl acetate<br />3.1: 96 percent / 2-methyl-propan-2-ol / 4 h / 40 &deg;C<br />4.1: n-BuLi; tetramethylethylenediamine / diethyl ether / -78 &deg;C<br />4.2: diethyl ether<br />5.1: methanol; CHCl₃; hexane / 2 h / 0 - 20 &deg;C<br />6.1: n-BuLi / tetrahydrofuran / 1 h / -78 &deg;C<br />6.2: AcOH / tetrahydrofuran / -78 - 20 &deg;C<br /> <br /> &nbsp;