DL-alpha-氨基辛二酸合成路线 （共 15 条）
反应条件
hydrogenchloride; water 6 h; Reflux;
参考文献
Gupta, Praveer K.; Reid, Robert C.; Liu, Ligong; Lucke, Andrew J.; Broomfield, Steve A.; Andrews, Melanie R.; Sweet, Matthew J.; Fairlie, David P.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 23 p. 7067 - 7070
反应条件
1.1: NaI / tetrahydrofuran / Heating 2.1: NaOEt / ethanol / 0.5 h 2.2: 1.25 g / ethanol / Heating 3.1: 540 mg / aq. HCl / Heating View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
反应条件
1.1: NaOEt / ethanol / 0.5 h 1.2: 1.25 g / ethanol / Heating 2.1: 540 mg / aq. HCl / Heating View Scheme
参考文献
Kahnberg, Pia; Lucke, Andrew J.; Glenn, Matthew P.; Boyle, Glen M.; Tyndall, Joel D. A.; Parsons, Peter G.; Fairlie, David P.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 26 p. 7611 - 7622
反应条件
1: Cl2 / H2SO4 2: aq. NH3 View Scheme
参考文献
Nesmeyanov,A.N. et al.
Tetrahedron, 1962 , vol. 17, p. 69 - 77
反应条件
sodium ethanolate in ethanol Heating;
参考文献
Lerch,E.; Hesse,M.
Helvetica Chimica Acta, 1974 , vol. 57, p. 1584 - 1597
参考文献
Nesmeyanov,A.N. et al.
Tetrahedron, 1962 , vol. 17, p. 69 - 77
参考文献
Nishino, Norikazu; Arai, Toru; Ueno, Yukio; Ohba, Masataka
Chemical and Pharmaceutical Bulletin, 1996 , vol. 44, # 1 p. 212 - 214
反应条件
hydrogenchloride Heating;
参考文献
Barraclough; Caldwell; Glen; Harris; Stepney; Whittaker; Whittle
Archiv der Pharmazie, 1993 , vol. 326, # 2 p. 85 - 95
反应条件
1: 1) NaOEt / 1) EtOH, 15 min, r.t., 2) EtOH, reflux 2: 3N HCl / Heating View Scheme
参考文献
Barraclough; Caldwell; Glen; Harris; Stepney; Whittaker; Whittle
Archiv der Pharmazie, 1993 , vol. 326, # 2 p. 85 - 95
反应条件
1: ethanol; sodium nitrit, aqueous 2: ethanolic KOH-solution 3: tin; aqueous HCl View Scheme
参考文献
Treibs; Reinheckel
Chemische Berichte, 1956 , vol. 89, p. 51,56
