反应条件
1: 1.) trimethylchlorosilane, hexamethyldisilazane, 2.) trimethylsilyl triflate / 1.) reflux, 3 h, 2.) CHCl3, RT, 1 h
2: 38 percent / 1N NaOEt / ethanol / Ambient temperature
3: 1.) triphenylphosphine, 2.) carbon tetrachloride, pyridine / 1.) DMF, 10 min, 2.) DMF, RT, 1.5 h
View Scheme
参考文献
Griengl, Herfried; Bodenteich, Michael; Hayden, Walter; Wanek, Erich; Streicher, Wolfgang; et al.
Journal of Medicinal Chemistry, 1985 , vol. 28, # 11 p. 1679 - 1684
