反应条件
1: 98 percent / imidazole / dimethylformamide / 1 h / Ambient temperature 2: 1) lithium hexamethyldisilazide / 1) THF, -78 deg C, 1h, 2) room temperature, 30 min 3: tetrahydrofuran / -78 °C 4: DIBAL-H / toluene / 2 h / -78 °C 5: 96 percent / pyridine, DMAP / CH2Cl2 / 2 h / 0 °C 6: 1) hexamethyldisilazane (HMDS), ammonium sulfate, 2) trimethylsilyl triflate (TMSOTf) / 1) reflux, 2 h, 2) 1,2-dichloroethane, a) 5 deg C, 10 min, b) room temperature, 10 min 7: 76 percent / 30percent aq. H2O2, pyridine / CH2Cl2 / 0.5 h / Ambient temperature 8: 78 percent / TBAF / tetrahydrofuran / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 14 p. 3887 - 3894
