2,6-二氯-9-(2,3,5-三-O-乙酰基-beta-D-呋喃核糖基)-9H-嘌呤合成路线 （共 15 条）
反应条件
1.1: 4 h / 20 °C 1.2: 92 percent / NH3 / methanol / 24 h / 20 °C 2.1: 68 percent / H2; 2 N NaOH / 10percent Pd/C / ethanol / 16 h / 2327.23 Torr View Scheme
参考文献
Vittori, Sauro; Lorenzen, Anna; Stannek, Christina; Costanzi, Stefano; Volpini, Rosaria; Ijzerman, Adriaan P.; Von Frijtag Drabbe Kunzel, Jakobien K.; Cristalli, Gloria
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 250 - 260
反应条件
1: T=20°C; Condensation; 4 h; 2: With ammonia in methanol T=20°C; Deacetylation; 24 h; Further stages.;
参考文献
Vittori, Sauro; Lorenzen, Anna; Stannek, Christina; Costanzi, Stefano; Volpini, Rosaria; Ijzerman, Adriaan P.; Von Frijtag Drabbe Kunzel, Jakobien K.; Cristalli, Gloria
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 250 - 260
反应条件
1.1: 4 h / 20 °C 1.2: 80 percent / NH3 / methanol / 24 h / 20 °C 2.1: 70 percent / H2; 2 N NaOH / 10percent Pd/C / ethanol / 16 h / 2327.23 Torr View Scheme
参考文献
Vittori, Sauro; Lorenzen, Anna; Stannek, Christina; Costanzi, Stefano; Volpini, Rosaria; Ijzerman, Adriaan P.; Von Frijtag Drabbe Kunzel, Jakobien K.; Cristalli, Gloria
Journal of Medicinal Chemistry, 2000 , vol. 43, # 2 p. 250 - 260
反应条件
1: ammonia / ethanol / 72 h / 20 °C 2: NH2NH2•xH2O / 10 h / 20 °C View Scheme
参考文献
El-Tayeb, Ali; Gollos, Sabrina
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 2 p. 436 - 447
反应条件
ammonia in ethanol T=100°C; 24 h;
参考文献
Major, Dan T.; Laxer, Avital; Fischer, Bilha
Journal of Organic Chemistry, 2002 , vol. 67, # 3 p. 790 - 802
