N,N-二乙基-2,3-二甲氧基苯甲酰胺合成路线 （共 9 条）
参考文献
Bringmann, Gerhard; Zhang, Guoliang; Hager, Anastasia; Moos, Michael; Irmer, Andreas; Bargou, Ralf; Chatterjee, Manik
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5778 - 5789
反应条件
1: DMF; oxalyl chloride / CH2Cl2 / 1 h 2: 5.7 g / CH2Cl2 / -45 °C View Scheme
参考文献
Bringmann, Gerhard; Zhang, Guoliang; Hager, Anastasia; Moos, Michael; Irmer, Andreas; Bargou, Ralf; Chatterjee, Manik
European Journal of Medicinal Chemistry, 2011 , vol. 46, # 12 p. 5778 - 5789
反应条件
1: N,N,N,N-tetramethylenediamine; s-butyllithium / tetrahydrofuran / 16 h / 20 °C 2: 1.57 g / potassium carbonate View Scheme
参考文献
Kamila, Sukanta; Mukherjee, Chandrani; Mondal, Sasanka S.; De, Asish
Tetrahedron, 2003 , vol. 59, # 8 p. 1339 - 1348
反应条件
1: 88 percent / sodium hydride / tetrahydrofuran / 20 °C 2: N,N,N,N-tetramethylenediamine; s-butyllithium / tetrahydrofuran / 16 h / 20 °C 3: 1.57 g / potassium carbonate View Scheme
参考文献
Kamila, Sukanta; Mukherjee, Chandrani; Mondal, Sasanka S.; De, Asish
Tetrahedron, 2003 , vol. 59, # 8 p. 1339 - 1348
反应条件
1: 88 percent / sodium hydride / tetrahydrofuran / 20 °C 2: N,N,N,N-tetramethylenediamine; s-butyllithium / tetrahydrofuran / 16 h / 20 °C 3: 1.57 g / potassium carbonate View Scheme
参考文献
Kamila, Sukanta; Mukherjee, Chandrani; Mondal, Sasanka S.; De, Asish
Tetrahedron, 2003 , vol. 59, # 8 p. 1339 - 1348
参考文献
Kamila, Sukanta; Mukherjee, Chandrani; Mondal, Sasanka S.; De, Asish
Tetrahedron, 2003 , vol. 59, # 8 p. 1339 - 1348
反应条件
1: 1) s-BuLi, N,N,N,N-tetramethylethylene diamine / 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h 2: NaBH4 / methanol / 3 h 3: aq. 2 N HCl / methanol / 1 h / Heating View Scheme
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
1: 1) s-BuLi, N,N,N,N-tetramethylethylene diamine / 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h
2: 10percent aq. HClO4 / 24 h / Heating
3: AcCl / 6 h
View Scheme
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
反应条件
1: 1) s-BuLi, N,N,N,N-tetramethylethylene diamine / 1) THF, cyclohexane, -78 deg C, 1 h, 2) to room temperature, 12 h
2: 10percent aq. HClO4 / 24 h / Heating
View Scheme
参考文献
De Silva; Reed; Billedeau; Wang; Norris; Snieckus
Tetrahedron, 1992 , vol. 48, # 23 p. 4863 - 4878
