6-溴-1-甲基-1,3-二氢-2H-苯并咪唑-2-酮合成路线 （共 6 条）
反应条件
trifluoroacetic acid in dichloromethane
T=20°C;
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Wrobel, Jay; Zhang, Zhiming; Zhu, Yuan; Cohen, Jeffrey; Marschke, Keith B.; Mais, Dale
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 20 p. 2747 - 2750
反应条件
in tetrahydrofuran
T=20°C; 18 h;
参考文献
AMGEN INC.
Patent: WO2009/11880 A2, 2009 ;
Location in patent: Page/Page column 157-158 ;
WO 2009/011880 A2
反应条件
in tetrahydrofuran
T=23°C; 17 h; Reflux;
参考文献
MERCK SHARP and DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2012/21382 A1, 2012 ;
Location in patent: Page/Page column 30 ;
WO 2012/021382 A1
反应条件
1: K2CO3 / acetonitrile / 20 °C
2: 95 percent / TFA / CH2Cl2 / 20 °C
View Scheme
参考文献
Zhang, Puwen; Terefenko, Eugene A.; Wrobel, Jay; Zhang, Zhiming; Zhu, Yuan; Cohen, Jeffrey; Marschke, Keith B.; Mais, Dale
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 20 p. 2747 - 2750
反应条件
1: ethanol; methanol / 13 h / 23 °C
2: zinc; acetic acid / 0.58 h
3: tetrahydrofuran / 17 h / 23 °C / Reflux
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2012/21382 A1, 2012 ;
WO 2012/021382 A1
反应条件
1: zinc; acetic acid / 0.58 h
2: tetrahydrofuran / 17 h / 23 °C / Reflux
View Scheme
参考文献
MERCK SHARP and DOHME CORP.; DUDKIN, Vadim; FRALEY, Mark, E.; ARRINGTON, Kenneth, L.; LAYTON, Mark, E.; RODZINAK, Kevin, J.; PERO, Joseph, E.; REIF, Alexander, J.
Patent: WO2012/21382 A1, 2012 ;
WO 2012/021382 A1
