4-(二溴亚甲基)哌啶-1-羧酸叔丁酯合成路线 （共 2 条）
反应条件
triphenylphosphine in dichloromethane T=0 - 20°C; 72 h; Inert atmosphere;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; RUPRAH, Parminder, Kaur; MERCHANT, Kevin, John; WALSH, Louise, Marie; KERR, Catrina, Morven; FIELDHOUSE, Charlotte; HARRISSON, David; MAINE, Stephanie; HAZEL, Katherine
Patent: WO2013/27001 A1, 2013 ;
Location in patent: Page/Page column 61 ;
反应条件
1: With ammonium chloride in tetrahydrofuran; methanol T=0°C; 0.5 h; Inert atmosphere; 2: With zinc in tetrahydrofuran; methanol T=20°C; 4 h; Inert atmosphere;
参考文献
WO2013/27001 A1, ;
Page/Page column 61-62 ;
