1.1: iPr2NEt / 24 h / 20 °C 2.1: KOH / methanol / 0.5 h / 20 °C 2.2: Bu3SnH; PdCl2(PPh3)2 / tetrahydrofuran / 1 h / 0 °C 2.3: N-bromosuccinimide / tetrahydrofuran / 0.5 h / 20 °C 3.1: tetrabutylammonium fluoride / tetrahydrofuran / 6 h / 20 °C View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587329', constants.ctx, '0')">tri-n-butyl-tin hydride</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '3679307', constants.ctx, '0')">dimethylaluminum chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=-78&deg;C;&nbsp;1&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: imidazole / CH₂Cl₂ / 6 h / 20 &deg;C<br />2.1: Me(OMe)NH*HCl; iPrMgCl / tetrahydrofuran / 0.5 h / 0 &deg;C<br />2.2: BuLi / tetrahydrofuran / 2 h / -78 &deg;C<br />3.1: Me₂AlCl; Bu₃SnH / CH₂Cl₂ / 3 h / -78 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1.1: imidazole / CH₂Cl₂ / 6 h / 20 &deg;C<br />2.1: Me(OMe)NH*HCl; i-PrMgCl / tetrahydrofuran / 0.5 h / 0 &deg;C<br />2.2: BuLi / tetrahydrofuran / 0.5 h / -78 &deg;C<br />3.1: 67 percent / dimethylaluminum chloride; Bu₃SnH / CH₂Cl₂ / 1 h / -78 &deg;C<br /> <br /> &nbsp;