苄基(5-氧代四氢-3-呋喃基)氨基甲酸酯合成路线 （共 3 条）
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=0°C; 3.5 h; 2: With hydrogenchloride in tetrahydrofuran; water pH=~ 2; 3: With toluene-4-sulfonic acid in benzene 3 h; Heating / reflux;
参考文献
CYTOKINETICS, INC.; SMITHKLINE BEECHAM CORPORATION
Patent: WO2005/107762 A2, 2005 ;
Location in patent: Page/Page column 268-270 ;
反应条件
hydrogenchloride; sodium borohydride; acetic anhydride; toluene-4-sulfonic acid in tetrahydrofuran; water; benzene
参考文献
KYORIN PHARMACEUTICAL CO., LTD.
Patent: EP443498 A1, 1991 ;
反应条件
4-(N,N-dimethlyamino)pyridine; triethylamine in dichloromethane T=0 - 20°C; 12.5 h;
参考文献
El Hadri, Ahmed; Abouabdellah, Ahmed; Thomet, Urs; Baur, Roland; Furtmueller, Roman; Sigel, Erwin; Sieghart, Werner; Dodd, Robert H.
Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2824 - 2831
