2-溴-1-(4-羟基甲基苯基)-1-戊酮合成路线 （共 6 条）
反应条件
bromine in chloroform
参考文献
Meltzer, Peter C.; Butler, David; Deschamps, Jeffrey R.; Madras, Bertha K.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1420 - 1432
反应条件
1: AlCl3 2: 1-methyl-pyrrolidin-2-one 3: HCl 4: (i) HOCH2CH2OH, TsOH, benzene, (ii) LiAlH4, Et2O, (iii) TsOH, acetone 5: Br2 / CHCl3 View Scheme
参考文献
Michaelis; Russel; Schindler
Journal of medicinal chemistry, 1970 , vol. 13, # 3 p. 497 - 503
反应条件
1: HCl 2: (i) HOCH2CH2OH, TsOH, benzene, (ii) LiAlH4, Et2O, (iii) TsOH, acetone 3: Br2 / CHCl3 View Scheme
参考文献
Michaelis; Russel; Schindler
Journal of medicinal chemistry, 1970 , vol. 13, # 3 p. 497 - 503
反应条件
1: (i) HOCH2CH2OH, TsOH, benzene, (ii) LiAlH4, Et2O, (iii) TsOH, acetone 2: Br2 / CHCl3 View Scheme
参考文献
Michaelis; Russel; Schindler
Journal of medicinal chemistry, 1970 , vol. 13, # 3 p. 497 - 503
反应条件
1: 1-methyl-pyrrolidin-2-one 2: HCl 3: (i) HOCH2CH2OH, TsOH, benzene, (ii) LiAlH4, Et2O, (iii) TsOH, acetone 4: Br2 / CHCl3 View Scheme
参考文献
Michaelis; Russel; Schindler
Journal of medicinal chemistry, 1970 , vol. 13, # 3 p. 497 - 503
反应条件
1: AlCl3 2: 1-methyl-pyrrolidin-2-one 3: HCl 4: (i) HOCH2CH2OH, TsOH, benzene, (ii) LiAlH4, Et2O, (iii) TsOH, acetone 5: Br2 / CHCl3 View Scheme
参考文献
Michaelis; Russel; Schindler
Journal of medicinal chemistry, 1970 , vol. 13, # 3 p. 497 - 503
