(S)-叔丁基 4-((r)-2-甲氧基-1-(4-(三氟甲基)苯基)乙基)-3-甲基哌嗪-1-羧酸合成路线 （共 9 条）
反应条件
in acetonitrile 19 h; Heating / reflux;
参考文献
Schering Corporation
Patent: US6391865 B1, 2002 ;
Location in patent: Page column 115 ;
US 6391865 B1
反应条件
1: borane dimethylsulfide; (S)-2-methyl-CBS-oxaborolidine / 1 h 2: triethylamine / CH2Cl2 / 0.5 h / cooling 3: 14.8 g / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
1: triethylamine / CH2Cl2 / 0.5 h / cooling 2: 14.8 g / K2CO3 / acetonitrile / 72 h / Heating View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
potassium carbonate in acetonitrile 72 h; Heating;
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
19 h; Product distribution / selectivity;
参考文献
Schering Corporation
Patent: US2003/208074 A1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
96 h; Product distribution / selectivity;
参考文献
Schering Corporation
Patent: US2003/208074 A1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
34 h; Product distribution / selectivity;
参考文献
Schering Corporation
Patent: US2003/208074 A1, 2003 ;
Location in patent: Page/Page column 10 ;
反应条件
1.1: 7.9 g / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C 2.1: Ti(OiPr)4 / CH2Cl2 / 20 h / 20 °C 2.2: 13.4 g / CH2Cl2; toluene / 20 h 3.1: 76 percent / tetrahydrofuran / 48 h / 20 °C View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
反应条件
1.1: 7.9 g / trifluoroacetic acid / CH2Cl2 / 3 h / 20 °C
2.1: Ti(OiPr)4 / CH2Cl2 / 20 h / 20 °C
2.2: 13.4 g / CH2Cl2; toluene / 20 h
3.1: 76 percent / tetrahydrofuran / 48 h / 20 °C
4.1: 100 percent / trifluoroacetic acid / CH2Cl2 / 6 h / 20 °C
View Scheme
参考文献
Tagat, Jayaram R.; McCombie, Stuart W.; Nazareno, Dennis; Labroli, Marc A.; Xiao, Yushi; Steensma, Ruo W.; Strizki, Julie M.; Baroudy, Bahige M.; Cox, Kathleen; Lachowicz, Jean; Varty, Geoffrey; Watkins, Robert
Journal of Medicinal Chemistry, 2004 , vol. 47, # 10 p. 2405 - 2408
