2,3-二甲氧基-5-甲基-1,4-苯二酚合成路线 （共 43 条）
反应条件
bromine in chloroform 2.5 h; Ambient temperature;
参考文献
Fujita, Yoshiji; Ishiguro, Michihiro; Onishi, Takashi; Nishida, Takashi
Synthesis, 1981 , # 6 p. 469 - 471
反应条件
scandium tris(trifluoromethanesulfonate) in nitromethane; hexane T=50°C; 16 h;
参考文献
WO2007/17168 A1, ;
Page/Page column 10 ;
反应条件
1: With H3[PW12O40] in nitromethane; n-heptane; water T=40°C; 3 h; 2: With acetic acid; silver(l) oxide in n-heptane T=20°C; 1 h; Product distribution / selectivity;
参考文献
DSM IP ASSETS B.V.
Patent: WO2007/17168 A1, 2007 ;
Location in patent: Page/Page column 12 ;
参考文献
Toyoda,M. et al.
Tetrahedron Letters, 1968 , p. 3837 - 3840
反应条件
(i) ZnCl2, Et2O, (ii) MnO2, PE; Multistep reaction;
参考文献
Schumacher,H.; Machleidt,H.
Angewandte Chemie, 1967 , vol. 79, p. 979 - 980
反应条件
1: NaOH / methanol
2: AlCl3 / CH2Cl2
View Scheme
参考文献
Jung, Young-Sik; Joe, Bo-Young; Cho, Sung Ju; Konishi, Yasuo
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1125 - 1129
反应条件
1: sodium hydroxide / ethanol; water / 0 - 20 °C
2: titanium tetrachloride / dichloromethane / 0 - 20 °C
3: potassium borohydride / ethanol / 0.5 h / 0 °C
4: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C
View Scheme
参考文献
Ma, Wei; Li, Da-Wei; Sutherland, Todd C.; Li, Yang; Long, Yi-Tao; Chen, Hong-Yuan
Journal of the American Chemical Society, 2011 , vol. 133, # 32 p. 12366 - 12369
反应条件
1: NaOH / methanol
2: TiCl4 / CH2Cl2
View Scheme
参考文献
Jung, Young-Sik; Joe, Bo-Young; Cho, Sung Ju; Konishi, Yasuo
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 4 p. 1125 - 1129
反应条件
in 1,4-dioxane
T=100°C; 2 h;
参考文献
Okamoto; Matsumoto; Watanabe; Kawada; Imamoto; Imada
Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 9 p. 3745 - 3755
反应条件
1: 82 percent / NaOH / ethanol; H2O / 0.75 h / Ambient temperature
2: 78 percent / HCl / H2O / 40 °C
3: 84 percent / CAN / acetonitrile; H2O / 1 h / 0 °C
4: 1.) Cp2ZrCl2, 2.) NiCl2, PPh3, n-BuLi / 1.) ClCH2CH2Cl, 0 deg C, 2.) THF, hexane. -78 deg C, 30 min, -78 deg C to 0 deg C, 1.75 h
View Scheme
参考文献
Lipshutz, Bruce H.; Kim, Sung-Kyu; Mollard, Paul; Stevens, Kirk L.
Tetrahedron, 1998 , vol. 54, # 7 p. 1241 - 1253
