4-溴-n-环丙基苯甲酰胺合成路线 （共 4 条）
反应条件
1: With triethylamine in dichloromethane T=20°C; 1 h; 2: With hydrogenchloride in dichloromethane; water T=20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2006/64251 A1, 2006 ;
Location in patent: Page/Page column 61 ;
WO 2006/064251 A1
反应条件
1: 4-bromophenylacetic acid With N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: anhydrous cyclopropylamine in N,N-dimethyl-formamide T=20°C;
参考文献
Jones, Clifford D.; Andrews, David M.; Barker, Andrew J.; Blades, Kevin; Byth, Kate F.; Finlay, M. Raymond V.; Geh, Catherine; Green, Clive P.; Johannsen, Marie; Walker, Mike; Weir, Hazel M.
Bioorganic and Medicinal Chemistry Letters, 2008 , vol. 18, # 24 p. 6486 - 6489
反应条件
1: 4-bromophenylacetic acid With N-ethyl-N,N-diisopropylamine; HATU in N,N-dimethyl-formamide T=20°C; 0.25 h; 2: anhydrous cyclopropylamine in N,N-dimethyl-formamide T=20°C;
参考文献
GENELABS TECHNOLOGIES, INC.
Patent: WO2007/70556 A2, 2007 ;
Location in patent: Page/Page column 91 ;
反应条件
potassium acetate; bis-triphenylphosphine-palladium(II) chloride in dimethyl sulfoxide T=80°C;
参考文献
US2007/265265 A1, ;
Page/Page column 104-105 ;
