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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
306776-02-3
合成路线
（共 16 条）
513-35-9
2-甲基-2-丁烯
+
942-24-5
吲哚-3-甲酸甲酯
→
反应条件
306776-02-3
反应条件
3-NO2-pyridine; copper diacetate; silver trifluoromethanesulfonate; palladium diacetate; acrylic acid methyl ester in acetonitrile T=40°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Luzung, Michael R.; Lewis, Chad A.; Baran, Phil S.
Angewandte Chemie, International Edition, 2009 , vol. 48, # 38 p. 7025 - 7029
Angewandte Chemie, 2009 , vol. 121, # 38 p. 7159 - 7163
79-22-1
氯甲酸甲酯
+
377073-10-4
→
反应条件
306776-02-3
反应条件
1: 3-bromo-1-(2-methylbut-3-en-2-yl)-1H-indole With tert.-butyl lithium in tetrahydrofuran T=-78 - 0°C; 2: methyl chloroformate in tetrahydrofuran T=-78 - 0°C;
参考文献
Yokokawa, Fumiaki; Sugiyama, Hideyuki; Aoyama, Toyohiko; Shioiri, Takayuki
Synthesis, 2004 , # 9 p. 1476 - 1480
1173659-14-7
→
反应条件
306776-02-3
反应条件
Lindlar catalyst; hydrogen T=20°C; P=912.061 - 1140.08 Torr; 3 h;
参考文献
Melkonyan; Topolyan; Karchava; Yurovskaya
Chemistry of Heterocyclic Compounds, 2008 , vol. 44, # 10 p. 1288 - 1290
496-15-1
吲哚啉
→
反应条件
306776-02-3
反应条件
1.1: 90 percent / CuI; i-Pr2NEt / tetrahydrofuran / 21 h / 50 °C 2.1: 91 percent / H2 / Lindlar's catalyst / methanol / 10 h / 20 °C / 760 Torr 3.1: 86 percent / MnO2 / toluene / 1 h / 20 °C 4.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 5.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 5.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
1604-29-1
1,1-二甲基丙-2-炔基乙酸酯
→
反应条件
306776-02-3
反应条件
1.1: 90 percent / CuI; i-Pr2NEt / tetrahydrofuran / 21 h / 50 °C 2.1: 91 percent / H2 / Lindlar's catalyst / methanol / 10 h / 20 °C / 760 Torr 3.1: 86 percent / MnO2 / toluene / 1 h / 20 °C 4.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 5.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 5.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
377073-07-9
→
反应条件
306776-02-3
反应条件
1.1: 91 percent / H2 / Lindlar's catalyst / methanol / 10 h / 20 °C / 760 Torr 2.1: 86 percent / MnO2 / toluene / 1 h / 20 °C 3.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 4.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 4.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
→
反应条件
反应条件
t-Bu-XantPhos; [Pd(η3-1,1-Me2allyl)(μ-Cl)]2; caesium carbonate in dichloromethane T=0 - 20°C; Inert atmosphere; Overall yield = 90 percent; Overall yield = 109.1 mg; regioselective reaction;
参考文献
Johnson, Kirsten F.; Van Zeeland, Ryan; Stanley, Levi M.
Organic Letters, 2013 , vol. 15, # 11 p. 2798 - 2801
377073-09-1
→
反应条件
306776-02-3
反应条件
1.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 2.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 2.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
377073-08-0
→
反应条件
306776-02-3
反应条件
1.1: 86 percent / MnO2 / toluene / 1 h / 20 °C 2.1: 95 percent / NBS / dimethylformamide / 0.5 h / 0 °C 3.1: t-BuLi / tetrahydrofuran; pentane / 0.5 h / -78 °C 3.2: 89 percent / tetrahydrofuran; pentane / 1.5 h / -78 - 0 °C View Scheme
参考文献
Sugiyama, Hideyuki; Yokokawa, Fumiaki; Aoyama, Toyohiko; Shioiri, Takayuki
Tetrahedron Letters, 2001 , vol. 42, # 41 p. 7277 - 7280
120-72-9
吲哚
→
反应条件
306776-02-3
反应条件
1: 96 percent / Br2 / dimethylformamide / 20 °C 2: 93 percent / NaH / dimethylformamide / 20 - 50 °C 3: 72 percent / tBuOK / tetrahydrofuran / 20 °C 4: 61 percent / DIBALH / CH2Cl2 / -78 °C 5: 70 percent / NaH / tetrahydrofuran / 20 °C 6: 89 percent / tBuLi / tetrahydrofuran / -100 - -78 °C View Scheme
参考文献
Della Sala, Giorgio; Capozzo, Daniela; Izzo, Irene; Giordano, Assunta; Iommazzo, Antonella; Spinella, Aldo
Tetrahedron Letters, 2002 , vol. 43, # 49 p. 8839 - 8841
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