2-乙酰氨基-3,4,6-三-O-乙酰-2-脱氧-α-D-吡喃葡萄糖酰基氯合成路线 （共 104 条）
反应条件
1.1: 4,4'-dimethoxytriphenylmethyl chloride; zinc(II) chloride / dichloromethane / 20 °C 2.1: sodium methylate / methanol / 2 h / 20 °C 2.2: Amberlite IRA-120 / 20 °C / pH 7 View Scheme
参考文献
Meng, Ying; Guo, Yibing; Ling, Yong; Zhao, Yahong; Zhang, Qi; Zhou, Xinyang; Ding, Fei; Yang, Yumin
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 18 p. 5577 - 5584
反应条件
1: 100 percent / NaN3; TBAHS; aq. NaHCO3 / CH2Cl2 2: NaOMe / methanol View Scheme
参考文献
Tetrahedron Letters, , vol. 42, # 7 p. 1325 - 1328
反应条件
3 A molecular sieve; mercury(II) iodide in 1,2-dichloro-ethane T=90 - 95°C; 0.5 h; Yields of byproduct given;
参考文献
Zemlyakov; Kur'yanov; Sidorova; Chirva
Russian Journal of Bioorganic Chemistry, 1998 , vol. 24, # 8 p. 551 - 558
反应条件
4 A molecular sieve; iodine; 2,3-dicyano-5,6-dichloro-p-benzoquinone in acetonitrile 12 h; Ambient temperature;
参考文献
Kartha, K.P. Ravindranathan; Aloui, Mahmoud; Field, Robert A.
Tetrahedron Letters, 1996 , vol. 37, # 48 p. 8807 - 8810
反应条件
sodium hydroxide; t-Bu4NBr in dichloromethane 0.75 h; Ambient temperature;
参考文献
Roy, Rene; Tropper, Francois
Synthetic Communications, 1990 , vol. 20, # 14 p. 2097 - 2102
反应条件
mercury dibromide in 1,2-dichloro-ethane
9 h; Heating;
参考文献
Carvalho, Ivone; Scheuerl, Shona L.; Kartha, K.P. Ravindranathan; Field, Robert A.
Carbohydrate Research, 2003 , vol. 338, # 10 p. 1039 - 1043
反应条件
1: 45 g / KH; 18-crown-6 / CH2Cl2 / 4 h / 0 - 20 °C
2: 18.4 g / K2CO3 / methanol; H2O / 20 °C
3: 95 percent / ZnCl2 / 22 h / 70 °C
View Scheme
参考文献
Pistia-Brueggeman, Gabriela; Hollingsworth, Rawle I.
Carbohydrate Research, 2003 , vol. 338, # 5 p. 455 - 458
反应条件
15-crown-5; sodium hydrogencarbonate in acetonitrile
T=20°C;
参考文献
Kur'yanov; Chupakhina; Zemlyakov; Kotlyar; Kamalov; Chirva
Russian Journal of Bioorganic Chemistry, 2001 , vol. 27, # 6 p. 385 - 389
反应条件
tin(II) trifluoromethanesulfonate; 4 A molecular sieve; N,N,N',N'-tetramethyl-urea in dichloromethane
48 h; Ambient temperature;
参考文献
Lubineau, Andre; Gallic, Joelle Le; Malleron, Annie
Tetrahedron Letters, 1987 , vol. 28, # 42 p. 5041 - 5044
反应条件
1: 72 percent / K2CO3 / acetone; toluene / 1 h / 50 °C
2: 81 percent / 4 Angstroem molecular sieves, methyl iodide / CH2Cl2 / 22 h / 50 °C / stereochemistry, activation by methyl iodide; other acceptors
View Scheme
参考文献
Mereyala; Gurijala
Carbohydrate Research, 1993 , vol. 242, p. 277 - 280
